German Institute of Human Nutrition
is a member of the Leibniz Association. The institute’s mission is to conduct experimental and clinical research in the field of nutrition and health, with the aim of understanding the molecular basis of nutrition-dependent diseases, and of developing new strategies for treatment and prevention (Website: http://www.dife.de/?lang=en).
We invite applications for the newly founded Junior Research Group Muscle Physiology and Metabolism (MPM) for
starting on 01.01.2021.
Type 2 diabetes (T2D) is a multifactorial and complex disorder that includes genetic predisposition. Yet, there is little doubt that obesity-induced insulin resistance and subsequent compensatory insulin secretion accelerates pancreatic islet exhaustion and thus the onset of T2D. In this project we will use novel, specific and reversible genetic tools to mobilize endogenous defenses against diabetes and obesity. This genetic tool is based on the CRISPR/Cas9 technology that has transformed genome editing. Instead of using CRISPR/Cas9 to cleave DNA, we use a modified nuclease-deficient Cas9 protein directed by guide RNAs to upregulate endogenous genes. We will apply a new CRISPR gene activation technology (CRISPRa) to upregulate Ucp1 and Gdf15 gene expression in skeletal muscle of insulin-resistant, obese mice. We will test the hypothesis that this simultaneous induction of Ucp1 and Gdf15 will correct insulin resistance and obesity by decreasing appetite, while increasing energy expenditure and glucose utilization. This project will establish the use of CRISPRa for the study and treatment of metabolic diseases. Under this umbrella, postdoctoral fellow will:
Your Skills and Requirements
The advertised position is available initially for 2 years. The level of salary will be determined on the basis of standard/tariff conditions, present qualifications and professional experience (TV-L, level E13).
Please send your application (motivation letter, cv, certificates and names with contact information for references) until latest October 23rd, 2020 with reference nr. 2020_W11_AP to:
German Institute of Human Nutrition Potsdam-Rehbrücke
Human Resources and Social Services
or per E-Mail to firstname.lastname@example.org
For further information please do not hesitate to contact:
Dr. Maximilian Kleinert, Junior Research Group Leader, E-Mail: Maximilian.Kleinert@dife.de
By submitting your application documents, you grant us the right to collect, process, and use your personal data exclusively for the application selection process. For further information about your rights according to the data protection law, please contact the department Human Resources and Social Services (email@example.com).Läs mer
|Titel||1 Postdoc (m/f/d)|
|Employer||German Institute of Human Nutrition (DIfE)|
|Job location||Arthur-Scheunert-Allee 114-116, 14558 Nuthetal|
|Publicerad||september 25, 2020|
|Sista ansökningsdatum||oktober 23, 2020|
|Ämnen||Fysiologi,   Näringslära och dietetik,   Biokemi,   Molekylärbiologi,   Endokrinologi  |